Peer-reviewed veterinary case report
No cationic trypsinogen gene mutations found in schnauzers
By Bishop, Micah A et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2004·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Evaluation of the cationic trypsinogen gene for potential mutations in miniature schnauzers with pancreatitis.
- Species:
- dog
Plain-English summary
Four miniature schnauzers with a history of pancreatitis were studied to see if genetic mutations in the cationic trypsinogen gene might be causing their condition. Researchers compared their DNA to that of a healthy miniature schnauzer and a mixed breed dog. The results showed that all dogs had the same gene sequence, indicating that, unlike in humans, mutations in this gene are not a significant factor in causing pancreatitis in miniature schnauzers. This suggests that other factors may be responsible for the disease in these dogs.
People also search for: miniature schnauzer pancreatitis causes · dog pancreatitis genetic testing · why does my schnauzer have pancreatitis
Abstract
The purpose of this study was to evaluate the cationic trypsinogen gene in miniature schnauzers for possible mutations. Genetic mutations have been linked with hereditary pancreatitis in humans. Four miniature schnauzers were selected on the basis of a clinical history of pancreatitis. One healthy miniature schnauzer and 1 healthy mixed breed canine were enrolled as controls. DNA was extracted from these canines using a commercial kit. Primers were designed to amplify the entire canine cationic trypsinogen cDNA sequence. A polymerase chain reaction (PCR) was performed and products were purified and sequenced. All sequences were then compared. The healthy control canine, a healthy miniature schnauzer, and the 4 miniature schnauzers with pancreatitis showed identical sequences of the cationic trypsinogen gene to the published sequence. We conclude that, in contrast to humans with hereditary pancreatitis, mutations of the cationic trypsinogen gene do not play a major role in the genesis of pancreatitis in the miniature schnauzer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15581228/