Peer-reviewed veterinary case report
Benazepril treatment reduces protein loss in cats with chronic kidney
By Mizutani, Hisashi et al.·Published in Journal of veterinary internal medicine·2006·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of the clinical efficacy of benazepril in the treatment of chronic renal insufficiency in cats.
- Species:
- cat
Plain-English summary
A group of 61 cats with chronic kidney disease (also known as chronic renal insufficiency) were given either a medication called benazepril or a placebo to see how it affected their health over six months. The cats receiving benazepril showed lower levels of protein in their urine, which is a good sign, and more of them were able to stay in the earlier stages of kidney disease without getting worse compared to those on the placebo. Overall, benazepril may help cats with chronic kidney disease live longer and healthier lives.
People also search for: cat chronic kidney disease treatment · benazepril for cats · how to manage cat kidney disease
Abstract
BACKGROUND: Chronic renal insufficiency (CRI) is a common disease in cats. Angiotensin-converting enzyme inhibitors (ACEI) have beneficial effects in humans with CRI by reducing the loss of protein in the urine and increasing life expectancy. HYPOTHESIS: The ACEI benazepril has beneficial effects on survival, clinical variables, or both as compared with placebo in cats with CRI. ANIMALS: 61 cats with naturally occurring CRI. METHODS: The cats were enrolled into a prospective, randomized, double-blind, placebo-controlled clinical trial. Cats received placebo or 0.5-1 mg/kg benazepril once daily for up to 6 months. RESULTS: Urine protein/urine creatinine ratios were significantly (P < .05) lower with benazepril as compared with placebo at days 120 and 180. Three cats with placebo and 1 cat with benazepril were removed prematurely from the study because of deterioration of CRI or death. Cats were classified into 4 stages of CRI according to the International Renal Interest Society (IRIS) classification scheme. Incidence rates of cats with IRIS classification stage 2 or stage 3 that remained in stage 2 or 3 without progressing to stage 4 were higher with benazepril (93 +/- 5%) as compared with placebo (73 +/- 13%). CLINICAL IMPORTANCE: These results suggest a potential for benazepril to delay the progression of disease, extend survival time, or both in cats with CRI.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17063698/