Peer-reviewed veterinary case report
Dog recovery and walking after knee surgery with stem cells vs
By Taroni, Mathieu et al.·Published in Frontiers in veterinary science·2017·Small Animal Surgery Department, France·View original on PubMed →
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Original publication title: Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study.
- Species:
- dog
Plain-English summary
A group of dogs that had surgery to fix a torn knee ligament (cranial cruciate ligament rupture) received either a single injection of special stem cells or a month-long course of pain medication (NSAIDs) after their surgery. Fourteen dogs completed the study, and while both treatments were safe and showed no significant differences in pain relief or movement over time, the dogs that received the stem cell injection had better bone healing after one month. This suggests that stem cell therapy could be a good option for dogs who can't take traditional pain medications after surgery.
People also search for: dog knee surgery recovery · stem cell treatment for dog arthritis · NSAIDs for dog pain management
Abstract
OBJECTIVE: Compare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs). STUDY DESIGN: Prospective, double-blinded, randomized, controlled, monocentric clinical study. ANIMALS: Sixteen client-owned dogs. MATERIALS AND METHODS: Dogs with unilateral CrCLR confirmed by arthroscopy were included. Allogeneic neonatal canine MSCs were obtained from fetal adnexa retrieved after C-section performed on healthy pregnant bitches. The dogs were randomly allocated to either the "MSCs group," receiving an IA injection of MSCs after TPLO, followed by placebo for 1 month, or the "NSAIDs group," receiving IA equivalent volume of MSCs vehicle after TPLO, followed by oral NSAID for 1 month. One of the three blinded evaluators assessed the dogs in each group before and after surgery (1, 3, and 6 months). Clinical score and gait and bone healing process were assessed. The data were statistically compared between the two groups for pre- and postoperative evaluations. RESULTS: Fourteen dogs (nine in the MSCs group, five in the NSAIDs group) completed the present study. No significant difference was observed between the groups preoperatively. No local or systemic adverse effect was observed after MSCs injection at any time point considered. At 1 month after surgery, bone healing scores were significantly higher in the MSCs group. At 1, 3, and 6 months after surgery, no significant difference was observed between the two groups for clinical scores and gait evaluation. CONCLUSION: A single IA injection of allogeneic neonatal MSCs could be a safe and valuable postoperative alternative to NSAIDs for dogs requiring TPLO surgery, particularly for dogs intolerant to this class of drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28642867/