Peer-reviewed veterinary case report
Cyclosporine dose effects on dog perianal fistula healing and symptoms
By House, Arthur K et al.·Published in Veterinary surgery : VS·2006·The Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Evaluation of the effect of two dose rates of cyclosporine on the severity of perianal fistulae lesions and associated clinical signs in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with perianal fistulae (painful lesions around the rear end) were treated with cyclosporine, a medication that helps reduce inflammation. The dogs received either a lower dose (2 mg/kg) or a higher dose (5 mg/kg) daily for eight weeks. After the treatment, both groups showed improvement, but the higher dose was more effective, with 40% of dogs experiencing complete relief from symptoms and 60% seeing a reduction in lesion size. This suggests that a daily dose of 5 mg/kg of cyclosporine can help manage these painful lesions in dogs.
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Abstract
OBJECTIVE: To investigate the effect of cyclosporine (2 or 5 mg/kg every 24 hours) on perianal fistulae (PAF) lesions. STUDY DESIGN: Blinded randomized, prospective trial. ANIMALS: Dogs (n = 20) with perianal fistulae. METHODS: Dogs were randomly assigned to administration of either 2 mg/kg (n = 10) or 5 mg/kg (n=10) of cyclosporine orally every 24 hours for 8 weeks. Lesion surface area was measured, lesion severity was graded using a visual analog scale, and the presence and severity of clinical signs recorded every 2 weeks. RESULTS: Lesion variables were significantly reduced in both groups after 8 weeks and owners also reported a reduction in clinical sign severity. The 5 mg/kg dose rate significantly accelerated lesion resolution compared with 2 mg/kg. In the 2 mg/kg group, 20% of dogs had complete resolution of clinical signs and 10% had resolution of lesions. In the 5 mg/kg group, 40% of dogs had complete resolution of clinical signs and 60% had resolution of lesions. CONCLUSIONS: A dose rate of 5 mg/kg every 24 hours was more effective at reducing the surface area and severity of PAF lesions than 2 mg/kg every 24 hours but less effective at resolving PAF lesions than previous studies using dose rates > or =5 mg/kg every 12 hours. CLINICAL RELEVANCE: Cyclosporine at 5 mg/kg every 24 hours may be useful for the palliation of PAF lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16911154/