Peer-reviewed veterinary case report
High dose 3-day enrofloxacin treats dog urinary infections safely
By Westropp, J L et al.·Published in Journal of veterinary internal medicine·2012·Department of Medicine and Epidemiology, United States·View original on PubMed →
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Original publication title: Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs.
- Species:
- dog
Plain-English summary
A group of healthy adult dogs with uncomplicated urinary tract infections (UTIs) were treated with either a high dose of enrofloxacin for three days or a standard antibiotic, amoxicillin-clavulanic acid, for 14 days. Both treatments were effective, with similar rates of microbiological and clinical cures, meaning most dogs showed improvement in their symptoms. The shorter enrofloxacin treatment was just as effective as the longer one, which could help make it easier for pet owners to follow through with treatment. This study suggests that a shorter course of enrofloxacin can be a good option for treating UTIs in dogs.
People also search for: dog urinary tract infection treatment · enrofloxacin for dog UTI · short antibiotic course for dog UTI
Abstract
BACKGROUND: Uncomplicated urinary tract infections (UTI) in dogs usually are treated with antimicrobial drugs for 10-14 days. Shorter duration antimicrobial regimens have been evaluated in human patients. HYPOTHESIS: A high dose short duration (HDSD) enrofloxacin protocol administered to dogs with uncomplicated UTI will not be inferior to a 14-day treatment regimen with amoxicillin-clavulanic acid. ANIMALS: Client-owned adult, otherwise healthy dogs with aerobic bacterial urine culture yielding ≥ 10(3) CFU/mL of bacteria after cystocentesis. METHODS: Prospective, multicenter, controlled, randomized blinded clinical trial. Enrolled dogs were randomized to group 1 (enrofloxacin 18-20 mg/kg PO q24h for 3 days) or group 2 (amoxicillin-clavulanic acid 13.75-25 mg/kg PO q12h for 14 days). Urine cultures were obtained at days 0, 10, and 21. Microbiologic and clinical cure rates were evaluated 7 days after antimicrobial treatment was discontinued. Lower urinary tract signs and adverse events also were recorded. RESULTS: There were 35 dogs in group 1 and 33 in group 2. The microbiologic cure rate was 77.1 and 81.2% for groups 1 and 2, respectively. The clinical cure rate was 88.6 and 87.9% for groups 1 and 2, respectively. Cure rates between groups did not differ according to the selected margin of noninferiority. CONCLUSIONS AND CLINICAL IMPORTANCE: HDSD enrofloxacin treatment was not inferior to a conventional amoxicillin-clavulanic acid protocol for the treatment of uncomplicated bacterial UTI in dogs. Further research is warranted to determine if this protocol will positively impact owner compliance and decrease the emergence of antimicrobial resistance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22486931/