Peer-reviewed veterinary case report
P-selectin and inflammation markers in atopic dog skin lesions
By de Mora, F et al.·Published in Veterinary immunology and immunopathology·2007·Department of Pharmacology, Spain·View original on PubMed →
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Original publication title: Evaluation of the expression of P-selectin, ICAM-1, and TNF-alpha in bacteria-free lesional skin of atopic dogs with low-to-mild inflammation.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin condition that causes itching) showed increased levels of a protein called P-selectin in their affected skin areas, even when there was low to mild inflammation and no bacterial infection present. This suggests that P-selectin may play a significant role in the inflammation process of atopic dermatitis. While other proteins, ICAM-1 and TNF-alpha, did not show a significant increase, there was some indication they might also be involved. Understanding these proteins better could help improve treatments for dogs suffering from this itchy skin condition.
People also search for: dog itching treatment · atopic dermatitis in dogs · P-selectin role in dog skin problems
Abstract
Canine atopic dermatitis (AD) is a pruritic skin condition that shares many clinical and pathophysiological features with its human counterpart. A major therapeutic challenge of AD is the control of the skin inflammatory process. A detailed knowledge of the pro-inflammatory molecules involved in cell recruitment in AD would allow for a better control of the disease. We thus have studied the protein expression of P-selectin, ICAM-1 and TNF-alpha in the lesional and non-lesional skin of atopic dogs that had been treated for bacterial infections. Despite a low-to-mild inflammatory process, P-selectin protein was clearly upregulated in the lesional skin areas when compared with non-lesional skin (four-fold average increase). This P-selectin upregulation was accompanied by signs of functional changes such as increased cell margination, and membrane-associated protein expression. Although the expression of ICAM-1 and TNF-alpha was not enhanced in the lesional versus the non-lesional skin, there was a trend towards a correlated upregulation of both molecules. Further studies will help elucidate the significance of the substantial overexpression of P-selectin in canine AD, in particular in a scenario where bacterial antigens are not contributing as pro-inflammatory stimuli.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17166594/