Peer-reviewed veterinary case report
Effects of metaflumizone-amitraz on sedation in dogs
By Zwijnenberg, Raphael & Muir, William·Published in Veterinary therapeutics : research in applied veterinary medicine·2009·Fort Dodge Animal Health, United States·View original on PubMed →
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Original publication title: Evaluation of the potential for interaction between a metaflumizone-amitraz combination and dexmedetomidine hydrochloride in dogs.
- Species:
- dog
Plain-English summary
A group of healthy beagles was given a combination of metaflumizone and amitraz before being sedated with dexmedetomidine to see if it affected their heart and blood pressure. The dogs showed higher oxygen levels after sedation when they had received the pretreatment, but their blood pressure and heart rate remained stable and similar to when they weren't pretreated. This suggests that the combination of metaflumizone and amitraz does not change how the dogs respond to the sedation.
People also search for: dog sedation safety · metaflumizone amitraz combination effects · beagle sedation heart rate
Abstract
This study investigated the effects on cardiovascular parameters, if any, of a commercially available combination of metaflumizone and amitraz administered to healthy, telemetered beagles that were subsequently sedated with dexmedetomidine. Dogs were sedated first without any pretreatment and then after pretreatment with metaflumizone and amitraz. Baseline values of all parameters were within normal limits for all dogs before the first anesthetic event. At 10 and 20 minutes after onset of sedation, oxygen saturation as measured by pulse oximetry was significantly higher for dogs that were pretreated with metaflumizone and amitraz. At all times after induction of sedation, blood pressure, heart rate, and baseline body temperature for dogs pretreated with metaflumizone and amitraz were not statistically different from when they were not pretreated. In conclusion, prior treatment with metaflumizone and amitraz did not influence the hemodynamic response to dexmedetomidine in telemetered dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19742447/