Peer-reviewed veterinary case report
How gum disease affects inflammation tests in diabetic dogs
By Franco-Martinez, Lorena et al.·Published in BMC veterinary research·2024·University of Murcia, Spain·View original on PubMed →
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Original publication title: Evaluation of the presence of gingivitis as confounding factor in assessing inflammatory status in serum and saliva of dogs with diabetes mellitus.
- Species:
- dog
Plain-English summary
A group of dogs with diabetes mellitus (DM) had their blood and saliva tested for inflammation markers to see how their condition compared to healthy dogs and those with gingivitis. The study found that dogs with DM had higher levels of certain inflammatory markers in both their blood and saliva than healthy dogs without gingivitis. Additionally, dogs with gingivitis showed different levels of these markers, indicating that oral health can affect inflammation measurements. This suggests that when assessing inflammation in diabetic dogs, it's important to consider their dental health.
People also search for: dog diabetes symptoms · gingivitis in dogs treatment · inflammatory markers in dog saliva
Abstract
The aim of this study was to evaluate the changes in the serum and salivary inflammatory markers induced by Diabetes mellitus (DM) in dogs and to assess the possible confounding effect of gingivitis. A panel of 13 cytokines was measured in the serum and saliva of dogs diagnosed with DM and compared with healthy dogs without gingivitis (control group 1; CG1) and dogs with gingivitis but otherwise healthy (control group 2; CG2). The results of the present study showed statistically significantly higher levels of IL-8, KC-like and MCP1 in the serum of dogs with DM compared to CG1 dogs. In the case of saliva, the DM group presented statistically higher GM-CSF, IL6, IL15, and MCP1 levels compared to CG1, and lower KC-like chemokine compared to CG2. Finally, gingivitis produced changes in saliva, with salivary levels of GM-CSF, IL-6, IL-7, IL-15, IP-10, KC-like, IL-10, IL-18, MCP1, TNFα being statistically significantly higher in the saliva of CG2 dogs compared to CG1. The results of the present study indicate that dogs with DM have altered cytokine levels in serum and saliva compared to healthy dogs. In addition, this study highlights the importance of taking oral health into account when determining cytokines in dogs, as gingivitis can significantly alter their concentrations. .
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38521919/