Peer-reviewed veterinary case report
Accuracy of Randox and Fuji tests for dog C-reactive protein levels
By An, Sung-Ah et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Evaluation of the Randox and Fuji Dri-Chem vcCRP-P assays of canine C-reactive protein.
- Species:
- dog
Plain-English summary
A study looked at two tests for measuring C-reactive protein (cCRP) in dogs, which helps detect inflammation. Blood samples from 71 dogs, some healthy and some with health issues, were tested using the Randox and Fuji assays, and both showed good accuracy compared to a standard test. The Randox test had a slight bias of -1.90%, while the Fuji test had a bias of -5.93%. Both tests were found to be reliable for measuring cCRP levels, but it's important to use the same test consistently for monitoring, as their results are not interchangeable.
People also search for: dog inflammation test · C-reactive protein test for dogs · Randox vs Fuji cCRP test
Abstract
In veterinary medicine, measurement of canine C-reactive protein (cCRP) is used widely to detect inflammatory diseases. We evaluated the precision of Randox and Fuji assays for cCRP, as well as accuracy, correlation, and agreement compared to a reference ELISA. Blood samples from 71 client-owned dogs (20 healthy, 51 diseased) were analyzed with the 3 assays. Inter-assay CVs were ~3.5% with both the Randox and Fuji assays. The mean biases were -1.90% for the Randox and -5.93% for the Fuji test; the targeted biases were ~8.5% for both assays. The CV, bias, and observed total error were acceptable for the 2 assays compared to ASVCP recommendations based on biological variation studies. The Spearman correlation coefficient for cCRP concentration compared with the reference ELISA was 0.83 for the Randox test and 0.92 for the Fuji test. Both assays measured cCRP precisely at intermediate and increased concentrations. Correlation with the reference ELISA was good, and both assays could be used to evaluate cCRP concentrations in veterinary practice. However, the assays did not reach analytical agreement; hence the results obtained by these assays are not interchangeable, and serial monitoring of cCRP requires the use of the same assay.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35792552/