Peer-reviewed veterinary case report
Risks of chemotherapy side effects in dogs with low platelets
By Finlay, J. et al.·Published in Veterinary and Comparative Oncology·2015·Perth Veterinary Oncology Perth Australia, Australia·View original on Crossref →
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Original publication title: Evaluation of the risks of chemotherapy in dogs with thrombocytopenia
- Species:
- dog
Plain-English summary
A group of dogs with low platelet counts (thrombocytopenia) were given standard chemotherapy to see if they would have more side effects like vomiting, diarrhea, or bleeding compared to dogs with normal platelet counts. The study found that dogs with low platelet counts did not have a higher risk of these issues after treatment. In fact, dogs with normal platelet counts were more likely to experience vomiting as a side effect. This suggests that chemotherapy can be safely administered to dogs with thrombocytopenia without increasing the risk of serious side effects.
People also search for: dog chemotherapy side effects · thrombocytopenia in dogs · dog vomiting after chemotherapy
Abstract
AbstractThrombocytopenia is commonly encountered in veterinary oncology. Currently, there are no standard guidelines regarding the administration of chemotherapy to the patients with thrombocytopenia. This observational epidemiological cohort study aimed to determine whether thrombocytopenic dogs were at increased risk of gastrointestinal adverse effects (vomiting, diarrhoea, inappetence) or haemorrhage following administration of standard doses of chemotherapy. The adverse effects following 77 prospectively identified episodes of thrombocytopenia (platelet count, <200 000 µL−1) were compared with the adverse effects experienced in a retrospective cohort (platelet count >200 000 µL−1), and evaluated by statistical analysis. Overall, there was no statistically significant difference in the incidence of gastrointestinal adverse effects or haemorrhage between thrombocytopenic and control dogs. The control group of dogs with lymphoma were statistically more likely to experience vomiting as an adverse effect of chemotherapy (P = 0.028). The results presented here showed no evidence for an increased risk of gastrointestinal adverse effects or haemorrhage in thrombocytopenic dogs after receiving standard doses of chemotherapy.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12146