Peer-reviewed veterinary case report
Titin-cap gene not linked to heart disease in Irish wolfhounds
By Philipp, U et al.·Published in Animal biotechnology·2008·Institute for Animal Breeding and Genetics, Germany·View original on PubMed →
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Original publication title: Evaluation of the titin-cap gene (TCAP) as candidate for dilated cardiomyopathy in Irish wolfhounds.
- Species:
- dog
Plain-English summary
A group of Irish wolfhounds with dilated cardiomyopathy (DCM), a serious heart condition, was studied to see if a specific gene called titin-cap (TCAP) was responsible for their illness. Researchers looked at the DNA of eight affected dogs and found that the gene mutations were not unique to Irish wolfhounds, as similar mutations were also present in other breeds. This suggests that TCAP is unlikely to be the cause of DCM in Irish wolfhounds. Understanding the genetic factors behind DCM can help in managing and treating this condition in affected dogs.
People also search for: Irish wolfhound heart problems · dilated cardiomyopathy in dogs · dog heart disease genetics
Abstract
Dilated cardiomyopathy (DCM) is a myocardial disorder characterized by left ventricular dilatation and impaired systolic contraction. Irish wolfhounds (IW) and other large breed dogs are most commonly disposed to DCM. We analyzed the titin-cap (TCAP, telethonin) gene as candidate for DCM. Genomic DNA was analyzed in eight DCM affected and five DCM-free IWs. cDNA was sequenced in one DCM-affected IW and two unaffected dogs, one Tibetan terrier and one Dachshund. Compared to the Boxer reference sequence, one sequence difference was identified in the 3'UTR and two in the intron sequence. In the IWs the sequences were monomorphic. In order to rule out a breed-specific haplotype that predisposes to DCM, the polymorphisms were genotyped in 24 Elo dogs, a breed mix established from nine different breeds. The analysis showed that the mutations were not restricted to IW. Moreover, 80% of the Elos were homozygous for the IW haplotype. We conclude that TCAP can most likely be eliminated as cause for DCM in IWs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18855248/