Peer-reviewed veterinary case report
How three blood tests compare for diagnosing pancreatitis in dogs
By Archer, F. J. et al.·Published in Journal of Veterinary Medicine Series A·1997·View original on Crossref →
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Original publication title: Evaluation of Three Pancreas Specific Protein Assays, TLI(Trypsin‐Like Immunoreactivity), PASP (Pancreas Specific Protein) and CA 19–9 (Glycoprotein) for use in the Diagnosis of Canine Pancreatitis
- Species:
- dog
Plain-English summary
A group of dogs with pancreatitis was tested for specific proteins in their blood to help diagnose the condition. The tests looked at three proteins: TLI, PASP, and CA 19-9. While PASP levels were higher in most dogs with pancreatitis, the increase was small, and TLI was only elevated in a few cases. Overall, these tests were found to be of limited use for diagnosing pancreatitis in dogs.
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Abstract
SummaryThree radioimmunoassays (RIA) for the pancreas specific proteins TLI, PASP and CA 19–9 were evaluated in serum from normal control dogs (n = 40) and dogs with pancreatitis (n = 20). Statistically significant differences (P < 0.05) were found for serum TLI and PASP levels between the control and pancreatitis groups. However, only 3/20 dogs with pancreatitis had serum TLI concentrations greater than the highest concentration in control dogs. Concentrations of PASP in serum were higher in 15/20 dogs with pancreatitis than in the control dogs. The magnitude of the increase in concentrations of PASP in pancreatitis was small in the majority of cases. Thus these assays are of limited clinical value in the diagnosis of pancreatitis. There was no cross‐reactivity with dog serum in the CA 19–9 assay.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1439-0442.1997.tb01092.x