Peer-reviewed veterinary case report
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
- Journal:
- Journal of neuroimmunology
- Year:
- 2005
- Authors:
- Bánvölgyi, Agnes et al.
- Affiliation:
- Department of Pharmacology and Pharmacotherapy
- Species:
- rodent
Abstract
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16188326/