Peer-reviewed veterinary case report
Feline chaphamaparvovirus found in dogs with respiratory and gut signs
By Piewbang, Chutchai et al.·Published in BMC veterinary research·2025·Department of Pathology·View original on PubMed →
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Original publication title: Evidence of feline chaphamaparvovirus in dogs: molecular detection, genetic recombination, and tissue localization.
- Species:
- dog
Plain-English summary
Four dogs were found to have a virus called feline chaphamaparvovirus (FChPV), which is usually seen in cats but has recently been detected in dogs. Three of these dogs showed signs of gastrointestinal issues, while one had respiratory symptoms. The virus was found in various tissues, especially the spleen and intestines, but no serious health problems were linked to it. This study suggests that while FChPV can infect dogs, its impact on their health is still unclear and needs more research.
People also search for: dog respiratory problems · dog gastrointestinal disease · feline chaphamaparvovirus in dogs · dog virus symptoms
Abstract
BACKGROUND: Feline chaphamaparvovirus (FChPV) is a parvovirus primarily identified in cats, and more recently detected in dogs—including the first confirmed canine report from China in 2023—suggesting potential cross-species transmission. However, its clinical significance and host adaptation remain unclear. This study investigated FChPV infection in dogs with respiratory and enteric diseases, assessed its genetic diversity, and determined viral localization. RESULTS: A total of 392 dogs were screened for FChPV using conventional PCR, whole-genome sequencing, and in situ hybridization (ISH). FChPV DNA was detected in 4 of 392 dogs (1.0%), with three exhibiting enteric disease and one presenting respiratory sign. Phylogenetic analysis clustered canine FChPV strains into two distinct clades, sharing 98.3–99.6% genetic similarity with feline strains. Genetic recombination event was found in one canine strain (CP003/Dog/2020), with the feline strains identified in China were served as putative major and minor parents. ISH confirmed the localization of FChPV DNA within inflammatory cells across multiple tissues, primarily in the spleen and intestines. Additional signals were also detected in the brain, though no significant pathological changes were observed. CONCLUSIONS: These findings extend previous canine reports by providing molecular and histopathological evidence of FChPV infection in dogs from Southeast Asia. The low detection rate and presence of co-infections complicate interpretation of pathogenicity. Further investigation is needed to clarify transmission dynamics, host adaptation, and clinical relevance in canine populations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-025-05219-4.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41408277/