Peer-reviewed veterinary case report
Canine kobuvirus in Vietnam and Thailand can evade dog immunity
By Van Nguyen, Tin et al.·Published in Scientific reports·2024·Faculty of Veterinary Science·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evolutionary dynamics of canine kobuvirus in Vietnam and Thailand reveal the evidence of viral ability to evade host immunity.
- Species:
- dog
Plain-English summary
A study found that canine kobuvirus (CaKoV), a virus linked to gastrointestinal disease in dogs, was present in both healthy dogs and those with diarrhea in Vietnam and Thailand. The virus was most commonly detected in puppies under six months old. In Vietnam, about 28% of dogs with gastrointestinal issues tested positive for CaKoV, while the rate was around 8% in Thailand. The research also showed that the virus can evade the dog's immune system, which may explain why some healthy dogs were infected. Understanding this virus can help veterinarians better diagnose and treat gastrointestinal issues in dogs.
People also search for: dog diarrhea virus · puppy gastrointestinal disease · canine kobuvirus symptoms · dog health issues diarrhea
Abstract
Canine kobuvirus (CaKoV) is a pathogen associated with canine gastrointestinal disease (GID). This study examined 327 rectal swabs (RS), including 113 from Vietnam (46 healthy, 67 with GID) and 214 from Thailand (107 healthy and 107 with GID). CaKoV was detected in both countries, with prevalences of 28.3% (33/113) in Vietnam and 7.9% (17/214) in Thailand. Additionally, CaKoV was found in both dogs with diarrhea and healthy dogs. CaKoV was mainly found in puppies under six months of age (30.8%). Co-detection with other canine viruses were also observed. The complete coding sequence (CDS) of nine Vietnamese and four Thai CaKoV strains were characterized. Phylogenetic analysis revealed a close genetic relationship between Vietnamese and Thai CaKoV strains, which were related to the Chinese strains. CDS analysis indicated a distinct lineage for two Vietnamese CaKoV strains. Selective pressure analysis on the viral capsid (VP1) region showed negative selection, with potential positive selection sites on B-cell epitopes. This study, the first of its kind in Vietnam, provides insights into CaKoV prevalence in dogs of different ages and healthy statuses, updates CaKoV occurrence in Thailand, and sheds light on its molecular characteristics and immune evasion strategies.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38802579/