Peer-reviewed veterinary case report
Exaggerated responses to stress in the BTBR T+tf/J mouse: an unusual behavioral phenotype.
- Journal:
- Behavioural brain research
- Year:
- 2009
- Authors:
- Benno, Robert et al.
- Affiliation:
- William Paterson University of New Jersey · United States
- Species:
- rodent
Abstract
This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18977396/