Peer-reviewed veterinary case report
Intravenous hyaluronan effects on joint fluid in dogs after ligament
By Canapp, S O et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2005·Department of Orthopedic Surgery and Sports Medicine, United States·View original on PubMed →
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Original publication title: Examination of synovial fluid and serum following intravenous injections of hyaluronan for the treatment of osteoarthritis in dogs.
- Species:
- dog
Plain-English summary
A group of 22 dogs with a torn cranial cruciate ligament underwent surgery and received either a hyaluronan injection or a saline solution to see how it affected their joint fluid. The researchers measured the viscosity and hyaluronan levels in the joint fluid before and after surgery. They found that the joint fluid from the injured legs had different characteristics compared to the healthy ones, but the treatment with hyaluronan did not show any significant benefits over the saline solution. Overall, the study suggests that while the joint fluid changes with injury, the hyaluronan treatment did not improve the condition in this case.
People also search for: dog knee surgery recovery · hyaluronan for dog arthritis · torn cruciate ligament treatment in dogs
Abstract
A randomized, blinded, prospective clinical trial was performed to determine the effects of intravenous (i.v.) administration of hyaluronan sodium (HA) on serum glycosaminoglycans (GAG) concentrations, synovial fluid (SF) hyaluronan concentrations and viscosity in dogs treated for unilateral rupture of the cranial cruciate ligament. Twenty-two dogs undergoing tibial plateau leveling osteotomy were used in this study. Synovial fluid from both stifles and serum were collected prior to surgery and at 2, 4, and 8 weeks following surgery. Dogs received either 1.0 ml (10 mg) of sodium hyaluronate (treatment group 1; n = 10) or equal volume of 0.9% NaCl (treatment group 2; n = 12), i.v. immediately, 2 and 4 weeks following surgery. Synovial fluid viscosity was evaluated using a magnetically driven, acoustically tracked, translating-ball rheometer. Synovial fluid HA disaccharide content was measured by fluorophore-assisted carbohydrate electrophoresis. Serum GAG concentrations were measured by alcian blue spectrophotometric assay. Data were analyzed using a Wilcoxon sign rank test (p < 0.05). Mean +/- SD viscosity (cP) was significantly higher (p = 0.011) in SF obtained from the intact stifle (450 +/- 604.1) than injured (54.8 +/- 60.8) prior to surgery. Mean +/- SD HA concentrations (ug/ml) were significantly higher (p = 0.02) in synovial fluid obtained from the injured stifles (281.4 +/- 145.9) than intact stifles (141.6 +/- 132.5). No significant difference was noted within or between treatment groups in SF viscosity, HA concentrations, or serum GAG concentrations at any time following surgery. Stifles with cranial cruciate ligament insufficiency had significant alterations in SF viscosity and HA concentrations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16594448/