Peer-reviewed veterinary case report
Excitotoxicity and ALS: New therapy targets an old mechanism.
- Journal:
- Cell reports. Medicine
- Year:
- 2024
- Authors:
- Smith, Hannah Louise et al.
- Affiliation:
- Edinburgh Medical School: Biomedical Sciences · United Kingdom
Abstract
Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al.present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1ALS mouse and ameliorating cell death.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38382464/