Peer-reviewed veterinary case report
Ocular melanosis gene ruled out in Cairn terriers
By Winkler, Paige A et al.·Published in Journal of negative results in biomedicine·2013·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Exclusion of eleven candidate genes for ocular melanosis in Cairn terriers.
- Species:
- dog
Plain-English summary
A group of Cairn terriers with ocular melanosis, a condition that causes progressive eye pigmentation and can lead to glaucoma and blindness, was studied to find the genetic cause. Researchers looked at 11 potential genes but found no evidence that any of them were responsible for this inherited eye problem. This means that the search for the specific gene linked to ocular melanosis in Cairn terriers continues, as none of the genes tested were associated with the condition.
People also search for: Cairn terrier eye problems · ocular melanosis in dogs · glaucoma treatment for Cairn terriers
Abstract
BACKGROUND: Ocular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness. Pedigree analysis suggests the trait has an autosomal dominant mode of inheritance. We selected 11 potential candidate genes and used an exclusion analysis approach to investigate the likelihood that one of the candidate gene loci contained the Cairn terrier-ocular melanosis locus. RESULTS: Two polymorphic loci were identified within or close to each candidate gene. Genotyping of at least 10 ocular melanosis Cairn terriers for each marker showed that there was no single shared allele for either of the two polymorphic markers identified in ASIP, COMT, GPNMB, GSK3B, LYST, MC1R, MITF, SILV, TYR, TYRP1,and TYRP2. This is strong evidence to exclude each locus as the site of the ocular melanosis mutation (probability of a false exclusion calculated for each gene ranged from 1.59 × 10-4 to 1 × 10-9). CONCLUSIONS: None of the 11 potential candidate genes selected are likely to be the gene locus for ocular melanosis in Cairn terriers.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23448350/