Peer-reviewed veterinary case report
Galectin 9 gene ruled out for high uric acid in Dalmatian dogs
By Bannasch, D L et al.·Published in Animal genetics·2004·Department of Population Health and Reproduction, United States·View original on PubMed →
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Original publication title: Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog.
- Species:
- dog
Plain-English summary
All Dalmatians have a genetic issue that causes them to excrete high levels of uric acid in their urine instead of the normal product, allantoin. This condition, known as hyperuricosuria, is linked to a problem in their liver rather than their kidneys. Researchers looked into a specific gene thought to be involved in this issue but found that it was not responsible for the defect. This means that while Dalmatians have this unique metabolic trait, the search for the exact genetic cause continues.
People also search for: Dalmatian uric acid problem · hyperuricosuria in dogs · dog liver issues · genetic conditions in Dalmatians
Abstract
All Dalmatian dogs have an inherited defect in purine metabolism leading to high levels of uric acid excretion in their urine (hyperuricosuria) rather than allantoin, the normal end product of purine metabolism in all other breeds of dog. Transplantation experiments have demonstrated that the defect is intrinsic to the liver and not the kidney. Uricase, the enzyme involved in the breakdown of urate into allantoin, has been shown to function in Dalmatian liver cells. Therefore, candidate genes for this defect include transporters of urate, a salt of uric acid, across cell membranes. We excluded one such urate transporter candidate, galectin 9, using a Dalmatian x Pointer backcross in which hyperuricosuria was segregating.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15265074/