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Peer-reviewed veterinary case report

Exercise training and sympathetic regulation in experimental heart failure.

Journal:
Exercise and sport sciences reviews
Year:
2004
Authors:
Zucker, Irving H et al.
Affiliation:
Department of Physiology and Biophysics · United States

Abstract

In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/15243206/