Peer-reviewed veterinary case report
Exocrine pancreatic insufficiency in the Eurasian dog breed--inheritance and exclusion of two candidate genes.
- Journal:
- Animal genetics
- Year:
- 2007
- Authors:
- Proschowsky, H F & Fredholm, M
- Affiliation:
- Department of Animal and Veterinary Basic Sciences
- Species:
- dog
Plain-English summary
Exocrine pancreatic insufficiency is a condition where a dog's pancreas doesn't produce enough enzymes, leading to symptoms like increased appetite, weight loss, and large, light-colored stools. This study looked at three families of Eurasian dogs to understand how this condition is passed down. The researchers found that it likely follows an autosomal recessive pattern, meaning both parents must carry the gene for a puppy to be affected. They also ruled out two specific genes that were previously thought to be linked to this condition. Overall, the findings help clarify the genetic basis of this disease in Eurasian dogs.
Abstract
Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the singles method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17302791/