Peer-reviewed veterinary case report
Inherited pancreatic enzyme deficiency in Eurasian dogs and gene study
By Proschowsky, H F & Fredholm, MĀ·Published in Animal geneticsĀ·2007Ā·Department of Animal and Veterinary Basic SciencesĀ·View original on PubMed ā
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Original publication title: Exocrine pancreatic insufficiency in the Eurasian dog breed--inheritance and exclusion of two candidate genes.
- Species:
- dog
Plain-English summary
A Eurasian dog was found to have exocrine pancreatic insufficiency, a condition where the pancreas doesn't produce enough enzymes, leading to symptoms like increased appetite, weight loss, and large, light-colored stools. Researchers studied three families of this breed and determined that the condition is likely inherited in an autosomal recessive manner, meaning both parents must carry the gene for a puppy to be affected. They also ruled out two specific genes as causes of this condition. Understanding the genetic basis can help breeders avoid passing this issue to future generations.
People also search for: Eurasian dog weight loss Ā· dog pancreatic insufficiency symptoms Ā· inherited diseases in dogs
Abstract
Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the singles method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17302791/