Peer-reviewed veterinary case report
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1.
- Journal:
- Developmental and comparative immunology
- Year:
- 2016
- Authors:
- Deloizy, Charlotte et al.
- Affiliation:
- VIM-INRA-Université · France
Plain-English summary
Researchers are working on better ways to identify specific immune cells in pigs, which are important for both farming and medical research. They created a new tool that helps recognize a type of immune cell called CD11c, which behaves similarly in pigs as it does in humans. They also developed another tool that targets a specific group of immune cells known as dendritic cells, which play a key role in the immune response. These new tools will help scientists study how these immune cells work in health and disease, and could lead to better vaccines and treatments for pigs. Overall, this research aims to improve our understanding of pig immune cells and their potential uses in veterinary medicine.
Abstract
Pig is a domestic species of major importance in the agro-economy and in biomedical research. Mononuclear phagocytes (MNP) are organized in subsets with specialized roles in the orchestration of the immune response and new tools are awaited to improve MNP subset identification in the pig. We cloned pig CD11c cDNA and generated a monoclonal antibody to pig CD11c which showed a pattern of expression by blood and skin MNP subsets similar to humans. We also developed a porcine XCL1-mCherry dimer which specifically reacted with the XCR1-expressing dendritic cell subset of the type 1 lineage in blood and skin. These original reagents will allow the efficient identification of pig MNP subsets to study their role in physiological and pathological processes and also to target these cells in novel intervention and vaccine strategies for veterinary applications and preclinical evaluations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27345169/