EXPERIMENTAL ARACHNOID FIBROSIS PRODUCED BY METRIZAMIDE IN THE DOG*

Abstract

The short‐term neurologic and long‐term leptomeningeal effects of repeated subarachnoid administration of metrizamide at concentrations of 170 mg I/ml and 300 mg I/ml were investigated in dogs. After two months, arachnoid fibrosis of varying degrees was present in all dogs that had received metrizamide at the higher concentration. The higher concentration of met‐rizamide was more epileptogenic than the concentration of 170 mg I/ml. The presence of subarachnoid hemorrhage was not considered to play a role in the development of the arachnoid fibrosis. Veterinary Radiology Vol. 21, No. 2, 1980; pp 78–81.