Peer-reviewed veterinary case report
Experimental cardiac hypertrophy induced by oral administration of mineralocorticoid and saline in rats.
- Journal:
- Angiology
- Year:
- 2012
- Authors:
- Voucharas, Christos et al.
- Affiliation:
- Department of Cardiovascular and Thoracic Surgery
- Species:
- rodent
Abstract
We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22007030/