Peer-reviewed veterinary case report
Low-dose doxycycline treatment for periodontitis in Beagles
By Kim, Se Eun et al.·Published in American journal of veterinary research·2013·Department of Veterinary Surgery and Ophthalmology, South Korea·View original on PubMed →
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Original publication title: Experimental determination of a subantimicrobial dosage of doxycycline hyclate for treatment of periodontitis in Beagles.
- Species:
- dog
Plain-English summary
A group of Beagles with gum disease (periodontitis) was treated with a low dose of doxycycline, an antibiotic, to see if it could help their condition without the side effects of higher doses. The dogs received either 1 or 2 mg of doxycycline per kilogram of body weight daily for a month, while a control group received no treatment. The results showed that the dogs given 2 mg/kg had less gum bleeding and better gum attachment compared to those who didn't receive the medication. This suggests that a low dose of doxycycline can effectively improve gum health in dogs with periodontitis.
People also search for: Beagle gum disease treatment · doxycycline for dog periodontitis · how to treat dog gingivitis
Abstract
OBJECTIVE: To identify a subantimicrobial dose of doxycycline hyclate (SDD) and for the treatment of periodontitis in dogs. ANIMALS: 20 healthy Beagles for measurement of serum doxycycline concentration and 15 Beagles with periodontitis for evaluation of the efficacy of the SDD. PROCEDURES: 5 dogs each received doxycycline hyclate PO at a dose of 1, 2, 3, or 5 mg/kg. Blood samples were collected before and after administration, and serum concentrations of doxycycline were measured via high-performance liquid chromatography. Mean serum doxycycline concentrations were calculated, and SDDs were identified. In a separate trial, the identified SDDs (1 or 2 mg/kg) were administered PO once a day for 1 month to dogs with periodontitis (n = 5/group) and a control group (5) was fed vehicle only during the same period. Degree of gingival attachment and bleeding on probing (present or absent) were recorded. Gingival samples were collected before and after the 1-month period from the same anatomic sites. Degree of matrix metalloproteinase inhibition in gingival samples was determined via gelatin zymography and compared among treatment groups. RESULTS: Mean serum doxycycline concentrations in healthy dogs that received 1 or 2 mg of doxycycline/kg were consistently significantly lower than the minimal inhibitory doxycycline concentration for treatment of periodontitis throughout the 24-hour posttreatment period. Zymographic intensities were lower in dogs given 1 and 2 mg/kg than in the control dogs, and the degree of gingival attachment and bleeding significantly improved in dogs given 2 mg/kg, compared with in the control dogs and dogs given 1 mg of doxycycline/kg. CONCLUSIONS AND CLINICAL RELEVANCE: A doxycycline dosage of 2 mg/kg daily appeared to be an appropriate subantimicrobial regimen for dogs with periodontitis. Furthermore, this dosage may be suitable for long-term treatment of gelatinolytic inflammatory diseases such as periodontitis in this species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23270357/