Peer-reviewed veterinary case report
Experimental model of atelectasis in newborn piglets.
- Journal:
- Respiratory care
- Year:
- 2014
- Authors:
- Comaru, Talitha et al.
- Affiliation:
- Postgraduate Program in Medicine-Pediatrics and Child Health.
Abstract
BACKGROUND: There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy. METHODS: Thirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis. RESULTS: The model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2-95%, P = .09). CONCLUSIONS: Our model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23821766/