Peer-reviewed veterinary case report
Experimental pharmacodynamics and analgesic efficacy of liposome-encapsulated hydromorphone in dogs.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2011
- Authors:
- Krugner-Higby, Lisa et al.
- Affiliation:
- University of Wisconsin-Madison · United States
- Species:
- dog
Abstract
The purpose of this study was to determine the experimental side effects of liposome-encapsulated hydromorphone (LE-Hydro) in beagles and to evaluate LE-Hydro analgesia in dogs undergoing ovariohysterectomies (OVH). Beagles were injected subcutaneously with 1-3 mg/kg LE-Hydro or 0.1 mg/kg hydromorphone. Dogs were evaluated for sedation, temperature, respiratory rate, and heart rate. OVH dogs were injected with 2 mg/kg LE-Hydro subcutaneously or 0.2 mg/kg morphine and 0.05 mg/kg acepromazine intramuscularly. Side effects of LE-Hydro were within clinically acceptable limits. The analgesic efficacy was superior in dogs administered LE-Hydro at 12 hr postsurgically. LE-Hydro provided adequate, durable analgesia in dogs undergoing OVH.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21498589/