Peer-reviewed veterinary case report
Liposome hydromorphone provides long pain relief after dog spay
By Krugner-Higby, Lisa et al.·Published in Journal of the American Animal Hospital Association·2011·University of Wisconsin-Madison, United States·View original on PubMed →
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Original publication title: Experimental pharmacodynamics and analgesic efficacy of liposome-encapsulated hydromorphone in dogs.
- Species:
- dog
Plain-English summary
A group of beagles undergoing spay surgery (ovariohysterectomy) received either a new pain medication called liposome-encapsulated hydromorphone (LE-Hydro) or standard pain relief. The dogs given LE-Hydro showed better pain control 12 hours after surgery compared to those receiving traditional morphine. Additionally, the side effects from LE-Hydro were minimal and within safe limits. Overall, LE-Hydro proved to be an effective option for managing pain in dogs after surgery.
People also search for: dog spay surgery pain relief · beagle pain medication · liposome-encapsulated hydromorphone for dogs
Abstract
The purpose of this study was to determine the experimental side effects of liposome-encapsulated hydromorphone (LE-Hydro) in beagles and to evaluate LE-Hydro analgesia in dogs undergoing ovariohysterectomies (OVH). Beagles were injected subcutaneously with 1-3 mg/kg LE-Hydro or 0.1 mg/kg hydromorphone. Dogs were evaluated for sedation, temperature, respiratory rate, and heart rate. OVH dogs were injected with 2 mg/kg LE-Hydro subcutaneously or 0.2 mg/kg morphine and 0.05 mg/kg acepromazine intramuscularly. Side effects of LE-Hydro were within clinically acceptable limits. The analgesic efficacy was superior in dogs administered LE-Hydro at 12 hr postsurgically. LE-Hydro provided adequate, durable analgesia in dogs undergoing OVH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21498589/