Peer-reviewed veterinary case report
Young puppies catching canine influenza virus H3N8 infection symptoms
By Deshpande, Muralidhar et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2009·Intervet/Schering-Plough Animal Health, United States·View original on PubMed →
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Original publication title: Experimental reproduction of canine influenza virus H3N8 infection in young puppies.
- Species:
- dog
Plain-English summary
A group of young puppies, aged 14 to 15 weeks, were intentionally exposed to the canine influenza virus (CIV) H3N8 to study its effects. After exposure, the puppies showed signs of respiratory illness, including coughing and nasal discharge, and they were found to shed the virus in their nasal secretions for about a week. The puppies also developed antibodies against the virus within two weeks. This study confirms that CIV can cause respiratory disease in dogs, highlighting the importance of vaccination and monitoring for symptoms in young pets.
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Abstract
Canine influenza virus (CIV) subtype H3N8 has emerged as a new pathogen with sustained transmission in the dog population in the United States. In this study, we report the experimental induction of respiratory disease in dogs using three CIV field isolates. Young (14 to 15 weeks of age) CIV-seronegative pups were challenged with one of three CIV isolates and monitored for clinical signs of respiratory disease, nasal virus shedding, seroconversion, lung lesions, and virus isolation from the lower respiratory tract. The challenged pups developed clinical signs and lung lesions typical of influenza virus infection, shed virus in their nasal secretions for 7 to 8 days after challenge, and exhibited serum antibodies at 7 and 14 days after challenge. Lung tissues and tracheal swabs collected at 3 and 6 days after challenge exhibited active virus replication. These results demonstrate that CIV causes respiratory disease in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19742446/