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Peer-reviewed veterinary case report

Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.

Journal:
Neuron
Year:
2019
Authors:
Sorrentino, Zachary A & Giasson, Benoit I
Affiliation:
Department of Neuroscience · United States

Abstract

Parkinson's disease is a neurodegenerative movement disorder; however, peripheral symptoms can arise decades prior. In this issue of Neuron, Kim et al. (2019) provide evidence that progressive α-synuclein aggregation initiating in the gut could be a pathogenic epicenter anatomically rippling throughout the nervous system.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/31437447/