Peer-reviewed veterinary case report
Exposure of mice to long-light: a new animal model to study depression.
- Journal:
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Year:
- 2010
- Authors:
- Becker, Astrid et al.
- Affiliation:
- Institute of Molecular Psychiatry · Germany
- Species:
- rodent
Abstract
Mood disorders are highly prevalent and often difficult to treat. One of the most important obstacles in research on depression is the limited availability of reliable and valid animal models. Here we demonstrate that the exposure of mice to artificial daylight for 22 h per day produces a spectrum of behavioral and endocrine symptoms reminiscent to those seen in animal models of depression. Oral administration of the antidepressant imipramine has strong impact on these symptoms. Our results indicate that long-light exposure of mice represents a simple new method to study depression.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20813511/