Peer-reviewed veterinary case report
CCL27 and CCL28 gene activity in dog skin with atopic dermatitis
By Maeda, Sadatoshi et al.·Published in The Journal of veterinary medical science·2008·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Expression analysis of CCL27 and CCL28 mRNA in lesional and non-lesional skin of dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy condition) had skin samples taken to study the levels of certain proteins involved in inflammation. The researchers found that one protein, CCL28, was higher in the affected skin, while another protein, CCL27, was lower compared to healthy skin. This suggests that CCL28 might be more important in causing the skin issues seen in these dogs. Understanding these differences could help improve treatments for dogs with skin allergies.
People also search for: dog skin allergy treatment · atopic dermatitis in dogs · why is my dog itching · dog skin problems CCL28 · dog allergy skin symptoms
Abstract
Chemokines are important regulators of the selective recruitment of inflammatory cells into sites of allergic inflammation. Since canine atopic dermatitis (AD) shares many clinical features of human AD, patterns of chemokine production in dogs may also be similar with those in humans. The aim of this study was to examine mRNA expression of CCL27 and CCL28 in lesional skin of dogs with AD to demonstrate similarity of chemokine production with human counterparts. RNA was extracted from skin biopsy specimens of 12 dogs with AD. The mRNA expression of CC chemokines (CCL4, CCL19, CCL20, CCL21, CCL24, CCL27 and CCL28) was analyzed by quantitative real-time PCR and was compared between lesional and non-lesional skin. Seven types of chemokines examined were constitutively expressed in both lesional and non-lesional skin. It was found that mRNA expression levels of CCL27 and CCL28 among the chemokines were significantly different between lesional and non-lesional skin (P<0.05). Expression level of CCL27 mRNA in lesional skin was significantly lower than that in non-lesional skin. On the other hand, CCL28 mRNA expression in lesional skin was found to be higher than that in non-lesional skin. These results suggest that CCL28 but not CCL27 may play important roles in immunopathogenesis of canine AD, indicating that experimental canine study may provide additional information that can be extrapolated to human AD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18250572/