Peer-reviewed veterinary case report
COX-2 enzyme activity in hip joints of dogs with osteoarthritis
By Lascelles, B Duncan X et al.·Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2009·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
- Species:
- dog
Plain-English summary
A group of dogs with hip joint pain due to osteoarthritis (OA) had their joint tissues analyzed to understand the pain mechanisms better. The study found that dogs with OA had higher levels of a protein called COX-2 in their hip joint tissues compared to normal dogs, suggesting it plays a role in their pain. The researchers concluded that targeting COX-2 and another protein called 5-LOX could help manage pain in dogs suffering from OA. This information may help veterinarians choose more effective treatments for dogs with joint pain.
People also search for: dog hip pain treatment · osteoarthritis in dogs · COX-2 inhibitors for dogs
Abstract
Understanding the neurobiology of pain in naturally occurring models of osteoarthritis (OA) may improve the understanding of human OA pain. Both COX and LOX have been associated with joint pain. This study evaluated COX-1, COX-2, and 5-LOX expression and activity in a naturally occurring canine model of secondary OA. Hip joint capsule with synovial tissue (HJC) and femoral head subchondral bone (FH) was collected from normal dogs and dogs undergoing total hip replacement for coxofemoral joint OA. Tissues were analyzed for COX-1, COX-2, and LOX protein, and PGE(2) and LTB(4). Significantly more COX-2 protein was present in OA HJC than normal joints (p = 0.0009). There was no significant difference in COX-1 or LOX protein, although LOX protein was increased (p = 0.069). PGE(2) concentration in normal and OA HJC was similar (p = 1.0). LTB(4) concentration in OA HJC was significantly greater than normal HJC (p = 0.028). Significantly more COX-1 (p = 0.0098), COX-2 (p = 0.0028), and LOX (p = 0.0095) protein was present in OA FH tissue compared to normal FH tissue. There were no differences in PGE(2) or LTB(4) concentration in normal and OA FH tissue (p = 0.77 and p = 0.11). Together, these data suggest both COX-2 and 5-LOX are appropriate targets for the management of pain associated with naturally occurring OA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19274754/