Peer-reviewed veterinary case report
Cannabinoid receptors found in dog skin mast cell tumors
By Rinaldi, Valentina et al.·Published in Research in veterinary science·2022·Faculty of Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at 37 dogs with skin tumors called mast cell tumors (MCTs) to see how certain receptors (CB1 and CB2) were expressed in these tumors. The dogs were divided into two groups based on the severity of their tumors: low-grade and high-grade. The findings showed that the CB1 and CB2 receptors were more active in low-grade tumors compared to high-grade tumors. This suggests that these receptors might play a role in how these tumors behave, which could help in understanding and treating them better in the future.
People also search for: dog mast cell tumor treatment · canine skin tumor symptoms · what are cannabinoid receptors in dogs
Abstract
Cannabinoid receptors (CB1 and CB2) belong to endocannabinoid system (ECS), which is also composed from endocannabinoids and the enzymatic systems involved in their biosynthesis and degradation. The expression of CB1 and CB2 have been previously identified in normal canine mast cell and in atopic dermatitis. Canine cutaneous mast cell tumours (cMCTs) are among the most common cutaneous neoplasms in dogs and have a highly variable clinical behaviour. Expression of CB1-CB2 was assessed by means of immunohistochemistry in thirty-seven dogs (from 2019 to 2021) with proven histological diagnosis of cMCT. Dogs were divided in two groups according to the Kiupel's grading system: high-grade (HG) cMCT and low-grade (LG) cMCT. A semiquantitative (score 0-3) and quantitative assessment of immunoreactivity (IR) was performed for each case. Our results show that there CB1 and CB2 are highly expressed in LG- cMCT, in contrast to HG- cMCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36179546/