Peer-reviewed veterinary case report
Cytokine gene changes in colorectal polyps of miniature dachshunds
By Ohta, Hiroshi et al.·Published in Veterinary immunology and immunopathology·2013·Department of Veterinary Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Expression of CD4+ T cell cytokine genes in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds.
- Species:
- dog
Plain-English summary
A group of miniature dachshunds with inflammatory colorectal polyps (ICRPs) were studied to understand the cause of their large bowel diarrhea. These polyps can lead to multiple small growths and a larger one in the colorectal area, resembling a form of inflammatory bowel disease (IBD). The researchers found that certain immune system signals (cytokines) were more active in the dogs with large polyps compared to those with smaller ones or healthy dogs. Specifically, a cytokine called IL-17A was significantly higher in the large polyps, suggesting it plays a key role in this condition. Understanding these signals could help veterinarians develop better treatments for affected dogs.
People also search for: miniature dachshund diarrhea treatment · dog inflammatory bowel disease symptoms · colorectal polyps in dogs
Abstract
Inflammatory colorectal polyps (ICRPs) in miniature dachshunds are recently recognized as a major cause of large bowel diarrhea in this dog breed in Japan. ICRPs are characterized by the formation of multiple small polyps and a space-occupying large polyp in the colorectal area, and are thought to be a novel form of inflammatory bowel disease (IBD). In humans, specific cytokine patterns attributed to T helper (Th)1, Th17 and regulatory T cells have important roles in the pathogenesis of IBD. Thus, the aim of the present study was to assess the gene expression of cytokines of T cell subsets in the colorectal mucosa from dogs with ICRPs. Colorectal mucosal specimens from 10 dogs with ICRPs and 14 control dogs were used in this study. Interferon (IFN)-γ, interleukin (IL)-4, IL-17A and IL-10 mRNA expression was assessed using quantitative real-time PCR. IL-17A mRNA expression was significantly increased in large polyps compared to small polyps and controls. IFN-γ and IL-10 mRNA expression in large polyps were significantly higher than in controls. There was no significant difference in IL-4 mRNA expression among the three groups. IL-17A is thought to play important roles in the pathogenesis of ICRPs. IL-10 up-regulation could oppose the proinflammatory function of IL-17A.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23953369/