Peer-reviewed veterinary case report
Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge.
- Journal:
- Avian pathology : journal of the W.V.P.A
- Year:
- 2007
- Authors:
- Tarpey, I et al.
- Affiliation:
- Intervet UK · United Kingdom
- Species:
- bird
Abstract
As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17364512/