Peer-reviewed veterinary case report
Expression of claudin-3 in the esophagus and larynx of rat reflux model.
- Journal:
- Auris, nasus, larynx
- Year:
- 2014
- Authors:
- Xu, Xiao Bing et al.
- Affiliation:
- Department of Otorhinolaryngology · China
- Species:
- rodent
Abstract
OBJECTIVE: The aim of this study was to investigate the association between laryngeal expression of claudin-3 and laryngopharyngeal reflux (LPR) in a rat reflux model. METHODS: Eight Wistar rats were divided into two groups. Four rats underwent total esophageal myectomy to induce reflux, and the remainder underwent a sham operation as a control. All animals were sacrificed 12 weeks after surgery to perform tissue histology and Western blot analysis. RESULTS: Lymphocyte infiltration increased significantly in the study group in both esophageal and laryngeal samples (P=0.001, 0.002, respectively). Both esophageal and laryngeal expressions of claudin-3 were significantly lower in the study group when compared with that in the control group (P=0.045, 0.037, respectively). CONCLUSION: The results of this study suggest that a decrease in claudin-3 could be a sensitive indicator of reflux laryngitis in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24928064/