Peer-reviewed veterinary case report
Expression of cyclooxygenase-2 in canine nasal carcinomas.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2008
- Authors:
- Impellizeri, Joseph A & Esplin, D Glen
- Affiliation:
- Veterinary Oncology Services · United States
- Species:
- dog
Abstract
Cyclooxygenase(COX)-2 expression was evaluated in 24 paraffin-embedded canine nasal carcinoma tissue samples by immunohistochemistry. Several different tumor types were represented, including carcinomas, adenocarcinomas and squamous cell carcinomas. COX-2 expression was identified in 17/24 cases (71%). The proportion of positive cells expressing COX-2 ranged from 10 to 95% and COX-2 expression was predominantly localized in the cytoplasm. Treatment with a COX-2 inhibitor should be investigated, along with the utilization of COX-2 expression as a prognostic marker.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17517527/