Peer-reviewed veterinary case report
Protein markers linked to bladder cancer in dogs with transitional
By Lee, J-Y et al.·Published in Research in veterinary science·2007·Department of Clinical Veterinary Science, Japan·View original on PubMed →
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Original publication title: Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma.
- Species:
- dog
Plain-English summary
A group of dogs with transitional cell carcinoma (TCC), a type of bladder cancer, was studied to understand the role of certain proteins associated with tumors. Out of 52 dogs, many showed high levels of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp), which may indicate how the cancer behaves and responds to treatment. The findings suggest that COX-2 might influence the levels of P-gp in these dogs. This information could help veterinarians develop better treatment strategies for dogs with TCC.
People also search for: dog bladder cancer treatment · transitional cell carcinoma in dogs · COX-2 in canine cancer
Abstract
Cyclooxygenase-2 (COX-2), P-glycoprotein (P-gp) and multi-drug resistance-associated protein (MRP) are considered important tumor-associated proteins in humans and dogs. In the present study, we immunohistochemically evaluated the expression of these proteins in canine patients with transitional cell carcinoma (TCC). Of 52 cases, 30 (57.7%) were positive for COX-2, 40 (76.9%) for P-gp, and only 10 (19.2%) for MRP. In addition, 27 samples (27/52, 51.9%) were positive for two markers, while 3 (5.7%) and 5 (9.6%) cases were positive and negative, respectively, for all three markers. No significant correlations were seen for COX-2 and P-gp on Fisher's exact test and Mann-Whitney's test, but a significance was seen on Spearman's rank correlation analysis using the IHC scoring system (P=0.043). These results suggest that P-gp expression is induced by overexpression of COX-2 in canine patients with TCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17316722/