Peer-reviewed veterinary case report
Expression of endothelin-1 and endothelin receptor a in canine ovarian tumours.
- Journal:
- Reproduction in domestic animals = Zuchthygiene
- Year:
- 2010
- Authors:
- Borzacchiello, G et al.
- Affiliation:
- Department of Pathology and Animal Health · Italy
- Species:
- dog
Abstract
Ovarian tumours have a low incidence in bitch. Endothelin (ET-1) and endothelin A receptor (ET-A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET-1 and ET-A expression. Seventeen out of twenty tumours were ET-1 positive. Eight out of twenty tumours were ET-A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET-1 and ET-A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20210880/