Peer-reviewed veterinary case report
EGFR and VEGF proteins found in malignant dog nasal tumors
By Shiomitsu, K et al.·Published in Veterinary and comparative oncology·2009·Department of Molecular Biomedical Science, United States·View original on PubMed →
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Original publication title: Expression of epidermal growth factor receptor and vascular endothelial growth factor in malignant canine epithelial nasal tumours.
- Species:
- dog
Plain-English summary
A study found that many dogs with nasal tumors had high levels of certain proteins that could affect their treatment. Specifically, 54% of the tumors showed signs of the epidermal growth factor receptor (EGFR), and 92% had the vascular endothelial growth factor (VEGF). These proteins are linked to how tumors grow and respond to radiation therapy. The researchers suggest that using medications to block these proteins, along with radiation, might help improve treatment outcomes for dogs with these types of tumors.
People also search for: dog nasal tumor treatment · canine cancer radiation therapy · EGFR inhibitors for dogs
Abstract
Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) signalling pathways play a role in carcinogenesis. Inhibition of EGF receptor (EGFR) and of VEGF is effective in increasing the radiation responsiveness of neoplastic cells both in vitro and in human trials. In this study, immunohistochemical evaluation was employed to determine and characterize the potential protein expression levels and patterns of EGFR and VEGF in a variety of canine malignant epithelial nasal tumours. Of 24 malignant canine nasal tumours, 13 (54.2%) were positive for EGFR staining and 22 (91.7%) were positive for VEGF staining. The intensity and percentage of immunohistochemically positive neoplastic cells for EGFR varied. These findings indicate that EGFR and VEGF proteins were present in some malignant epithelial nasal tumours in the dogs, and therefore, it may be beneficial to treat canine patients with tumours that overexpress EGFR and VEGF with specific inhibitors in conjunction with radiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19453364/