Peer-reviewed veterinary case report
Expression of feline interferon-alpha subtypes in Esherichia coli, and their antiviral activity and animal species specificity.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2005
- Authors:
- Taira, Osamu et al.
- Affiliation:
- Department of Veterinary Microbiology · United States
- Species:
- cat
Abstract
Two kinds of FeIFN-alpha consisting of 166 amino acids (aa) and 171 aa were expressed in Escherichia coli, and the purified proteins were tested for antiviral activity on homologous and heterologous animal cells. Crude FeIFN induced in feline cells revealed antiviral activity on both homologous and heterologous animal cells. In contrast, both types of recombinant FeIFN-alpha revealed antiviral activity only on the feline cells. All of the FeIFN-alpha subtypes showed high activity to vesicular stomatitis virus, and the three species of feline viruses belonging to different families.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15942143/