Peer-reviewed veterinary case report
Expression of IL‐33 in chronic lesional skin of canine atopic dermatitis
- Journal:
- Veterinary Dermatology
- Year:
- 2018
- Authors:
- Asahina, Ryota et al.
- Affiliation:
- Department of Veterinary Medicine Faculty of Applied Biological Sciences Gifu University 1‐1 Yanagido Gifu 501‐1193 Japan · Japan
- Species:
- dog
Abstract
BackgroundIn humans, interleukin (IL)‐33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL‐33 is involved in the pathogenesis of canine atopic dermatitis (cAD).ObjectivesTo examine the expression of IL‐33 in chronic lesional skin of cAD.AnimalsEight dogs with spontaneous cAD and five healthy dogs were used.MethodsThe transcription of il‐33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL‐33 was evaluated immunohistochemically using an anti‐human IL‐33 monoclonal antibody with cross‐reactivity to canine IL‐33.ResultsThe transcription levels of il‐33 in chronic lesional skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL‐33 production in chronic lesional skin of cAD.Conclusions and clinical importanceThe results indicate that IL‐33 is involved in chronic lesional skin of cAD.
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Search related cases →Original publication: https://doi.org/10.1111/vde.12531