Peer-reviewed veterinary case report
IL-33 protein is higher in chronic skin lesions of dogs with atopic
By Asahina, Ryota et al.·Published in Veterinary Dermatology·2018·Department of Veterinary Medicine Faculty of Applied Biological Sciences Gifu University 1‐1 Yanagido Gifu 501‐1193 Japan, Japan·View original on Crossref →
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Original publication title: Expression of IL‐33 in chronic lesional skin of canine atopic dermatitis
- Species:
- dog
Plain-English summary
A group of eight dogs with chronic skin issues related to atopic dermatitis (a common allergic skin condition) showed higher levels of a protein called IL-33 in their affected skin compared to healthy dogs. This suggests that IL-33 plays a role in the inflammation seen in these dogs. The study found that skin cells called keratinocytes were the main source of IL-33 in the affected areas. Understanding this could help veterinarians develop better treatments for dogs suffering from atopic dermatitis.
People also search for: dog itchy skin treatment · canine atopic dermatitis causes · IL-33 in dogs skin problems
Abstract
BackgroundIn humans, interleukin (IL)‐33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL‐33 is involved in the pathogenesis of canine atopic dermatitis (cAD).ObjectivesTo examine the expression of IL‐33 in chronic lesional skin of cAD.AnimalsEight dogs with spontaneous cAD and five healthy dogs were used.MethodsThe transcription of il‐33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL‐33 was evaluated immunohistochemically using an anti‐human IL‐33 monoclonal antibody with cross‐reactivity to canine IL‐33.ResultsThe transcription levels of il‐33 in chronic lesional skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL‐33 production in chronic lesional skin of cAD.Conclusions and clinical importanceThe results indicate that IL‐33 is involved in chronic lesional skin of cAD.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.12531