Peer-reviewed veterinary case report
IL-33 protein levels in chronic skin lesions of dogs with atopic
By Asahina, Ryota et al.·Published in Veterinary dermatology·2018·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Expression of IL-33 in chronic lesional skin of canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of eight dogs with chronic skin issues due to atopic dermatitis (a common allergic skin condition) had higher levels of a protein called IL-33 in their affected skin compared to healthy dogs. This protein is linked to inflammation and may play a role in the ongoing skin problems these dogs experience. The study suggests that targeting IL-33 could be a potential approach for treating dogs with this condition. If your dog has persistent skin irritation or itching, discussing IL-33 and its role in treatment with your veterinarian might be beneficial.
People also search for: dog itchy skin treatment · atopic dermatitis in dogs · IL-33 in dog skin problems
Abstract
BACKGROUND: In humans, interleukin (IL)-33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis (cAD). OBJECTIVES: To examine the expression of IL-33 in chronic lesional skin of cAD. ANIMALS: Eight dogs with spontaneous cAD and five healthy dogs were used. METHODS: The transcription of il-33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL-33 was evaluated immunohistochemically using an anti-human IL-33 monoclonal antibody with cross-reactivity to canine IL-33. RESULTS: The transcription levels of il-33 in chronic lesional skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL-33 production in chronic lesional skin of cAD. CONCLUSIONS AND CLINICAL IMPORTANCE: The results indicate that IL-33 is involved in chronic lesional skin of cAD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29498117/