Peer-reviewed veterinary case report
Inflammation markers in dog knees after cruciate ligament rupture
By El-Hadi, Mustafa et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2012·Department of Veterinary Biomedical Sciences, Canada·View original on PubMed →
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Original publication title: Expression of interleukin-8 and intercellular cell adhesion molecule-1 in the synovial membrane and cranial cruciate ligament of dogs after rupture of the ligament.
- Species:
- dog
Plain-English summary
A group of 23 dogs with a torn cranial cruciate ligament (CCL) showed signs of inflammation in their knee joints, including increased levels of certain inflammatory markers. The study found that the synovial fluid from these dogs had more neutrophils, a type of white blood cell involved in inflammation, compared to healthy dogs. This suggests that after a CCL injury, the body responds with increased inflammation, which could contribute to pain and swelling. Understanding these changes can help veterinarians better manage treatment for dogs with CCL injuries.
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Abstract
This cross-sectional clinical study compared inflammation, including expression of the chemokine interleukin (IL)-8 and intercellular cell adhesion molecule-1 (ICAM-1), in the stifle joints of 4 control dogs and 23 dogs with cranial cruciate ligament rupture (CCLR). The CCL, synovial membrane, meniscus, cartilage, and synovial fluid from the affected stifle joints of all the dogs were examined. Inflammatory cell counts were performed on the synovial fluid, and the tissues were processed for histologic study and immunohistochemical detection of IL-8 and ICAM-1. The synovial fluid from the stifle joints of the dogs with CCLR had an increased percentage of neutrophils (P = 0.054) and a decreased percentage of lymphocytes (P = 0.004) but not macrophages compared with the fluid from the control dogs. There was accumulation of inflammatory cells and increased expression of IL-8 and ICAM-1 in the vascular endothelium of the synovial membrane and the CCL of the dogs with CCLR. The increase in inflammatory cells in the stifle joints of dogs with CCLR may therefore be due to increased expression of IL-8 and ICAM-1 in the synovial membrane and the CCL after the injury. These data may help in understanding the mechanisms of inflammation associated with CCLR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22754089/