Peer-reviewed veterinary case report
Expression of microRNAs miR-21 and miR-181c in cerebrospinal fluid and serum in canine meningoencephalomyelitis of unknown origin.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2016
- Authors:
- Gaitero, L et al.
- Affiliation:
- Ontario Veterinary College · Canada
- Species:
- dog
Abstract
The potential of microRNAs (miRNAs) as biomarkers for canine meningoencephalomyelitis of unknown origin (MUO) was investigated by using quantitative real-time (qRT)-PCR to determine the expression of microRNA-21 (miR-21) and microRNA-181c (miR-181c) in the cerebrospinal fluid (CSF) of dogs. Dogs with MUO (n = 10) had higher levels of expression of miR-21 and miR-181c in the CSF than dogs with non-inflammatory neurological diseases (n = 8). There was a positive correlation between CSF cellularity and expression of miRNAs in the CSF, particularly for miR-21 in the MUO group.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27687938/