Peer-reviewed veterinary case report
Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and evaluation of its protective effects.
- Journal:
- The Journal of parasitology
- Year:
- 2005
- Authors:
- Shirafuji, Hiroaki et al.
- Affiliation:
- Obihiro University of Agriculture and Veterinary Medicine · Japan
- Species:
- rodent
Abstract
In this study, P23 of Cryptosporidium parvum sporozoites, an immunodominant surface protein, was stably expressed in Toxoplasma gondii (Tg/P23) and its protective effects were evaluated in a mouse model. The molecular weight and antigenic property of P23 expressed by Tg/P23 were similar to those of the native P23. Mice immunized with lysed Tg/P23 tachyzoites produced specific neutralizing antibodies against C. parvum. These findings indicate that the T. gondii vector may provide a new tool for the production of a recombinant vaccine against cryptosporidiosis in animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15986633/