Peer-reviewed veterinary case report
PDGFR-beta and Kit protein in dog anal sac cancer cells
By Brown, R J et al.·Published in Veterinary and comparative oncology·2012·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Expression of PDGFR-β and Kit in canine anal sac apocrine gland adenocarcinoma using tissue immunohistochemistry.
- Species:
- dog
Plain-English summary
A dog with anal sac cancer was studied to understand how certain proteins might affect the disease. Researchers looked at tissue samples from both cancerous and normal anal sacs and found that a small number of tumors showed signs of specific proteins that could be linked to cancer growth. This suggests that these proteins might play a role in how the cancer develops and could help guide future treatments. While this study doesn't provide direct treatment outcomes, it highlights the need for more research into how these proteins could be targeted in therapy.
People also search for: dog anal sac cancer treatment · canine cancer protein markers · anal sac tumor in dogs
Abstract
Canine anal sac apocrine gland adenocarcinoma (ASAGAC) is an uncommon but highly invasive and metastatic malignancy. Toceranib phosphate (Palladia) is a receptor tyrosine kinase (RTK) inhibitor that targets several members of the split kinase RTK family. These membrane receptors are important for cell cycling, apoptosis and angiogenesis, all of which can contribute to carcinogenesis. The objective of this study was to evaluate archived, paraffin-embedded canine ASAGAC and normal canine anal sacs for immunohistochemical detection of Kit and platelet-derived growth factor receptor beta (PDGFR-β). Two of 77 neoplasms (2.6%) expressed Kit. Fifteen of the neoplasms (19.5%) were positive for PDGFR-β expression. None of the normal canine anal sac epithelium expressed Kit or PDGFR-β. Because of these results, further investigation should be considered to determine the role of RTKs in the clinical course and treatment of canine ASAGAC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22235855/