Peer-reviewed veterinary case report
c-kit protein linked to aggressive skin mast cell tumors in dogs
By Passantino, Letizia et al.·Published in Immunopharmacology and immunotoxicology·2008·Department of Animal Health and Welfare, Italy·View original on PubMed →
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Original publication title: Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors.
- Species:
- dog
Plain-English summary
A dog with a skin tumor called a mast cell tumor (MCT) was studied to understand how a specific gene, c-kit, affects the tumor's behavior. Mast cell tumors are common in dogs and can be more aggressive than in other animals. The research found that higher levels of c-kit expression in these tumors were linked to a more aggressive form of the disease. This suggests that checking c-kit levels could help veterinarians better predict how the tumor might behave and guide treatment decisions.
People also search for: dog skin tumor treatment · mast cell tumor in dogs · c-kit expression in canine tumors
Abstract
Canine cutaneous mast cell tumor (MCT) is very common disease in dogs, this is more aggressive than in other species. The biologic behavior of MCT is highly variable and a more accurate prognosis for these tumors needs to performed. The proto-oncogene c-kit is known to play a critical role in development and function of mast cells (MC). The aim of this study was to evaluate the expression of immunohistochemical pattern of c-kit in MCTs and to correlate these results with MC density (MCD) and intratumoral microvessel density (MVD). Our results confirm that a more aggressive biologic behavior of canine MCT is associated with the increased c-kit expression, further suggesting a new role for c-kit, as a useful marker, in diagnostic pathology and in tumor progression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18608529/