Peer-reviewed veterinary case report
YAP protein activity in dog skin tumors and cancer
By Sanz Ressel, Berenice Liyare et al.·Published in Research in veterinary science·2020·Laboratorio de Histologí·View original on PubMed →
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Original publication title: Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis.
- Species:
- dog
Plain-English summary
A study found that dogs with skin tumors, specifically cutaneous papillomas (CP) and cutaneous squamous cell carcinoma (CSCC), showed increased levels of a protein called YAP, which is involved in tumor development. This suggests that YAP could be a key player in the growth of these tumors and might be a target for new treatments. Understanding how YAP works in these skin tumors could lead to better therapies for affected dogs.
People also search for: dog skin tumor treatment · canine papilloma signs · squamous cell carcinoma in dogs
Abstract
Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis process could be the basis for the development of novel molecular mechanism-based antitumour treatments for CP and CSCC canine patients. Recent evidence suggests that the development and progression of CP and CSCC involve the dysregulated activation of the Hippo signalling pathway effector YAP. Thus, in the present study, we evaluated the immunohistochemical expression pattern of YAP in sections of tissue microarrays constructed from canine samples of normal epidermis, CP, preneoplastic epidermis, and CSCC. In samples of CP, preneoplastic epidermis, and CSCC, YAP expression was significantly increased relative to normal epidermis. This emerging evidence suggests that the dysregulated activity of the Hippo signalling pathway effector YAP represents a frequent event during canine epidermal tumourigenesis, pointing to this protein as a potential therapeutic target for the treatment of CP and CSCC in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32155472/